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PMX 205 Trifluoroacetate is a potent complement antagonist of C5a (C5aR; CD88) receptor. PMX 205 is orally active, PMX 205 (1 mg/kg/day; oral) treated display a significant extension of survival time and a reduction in end-stage motor scores, as compared with vehicle-treated rats. In 3xTg mice, PMX205 also significantly reduced hyperphosphorylated tau (69%).
| Molecular Weight | 953.06 |
| Formula | C47H63F3N10O8 |
| CAS Number | 514814-49-4 (free base) |
| Solubility (25°C) | DMSO 95 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Complement System Products |
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C5aR-IN-1 is a potent inhibitor of C5aR. |
| EG01377 dihydrochloride
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| Empasiprubart
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| Avacincaptad pegol sodium
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