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JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 µM) and reduces TNF levels (EC50=4.5 µM).
JPE-1375 (1 mg/kg; i.v.; single) demonstrates a rapid distribution in the plasma, followed by elimination in mice, and shows a strong negative correlation between PMN mobilization and TNF production with plasma concentrations.
| Molecular Weight | 955.08 |
| Formula | C49H63FN10O9 |
| CAS Number | 1254036-23-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 96 mg/mL |
| Storage | 4°C, protect from light |
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