Free shipping on all orders over $ 500

PLpro inhibitor

Cat. No. M9641
PLpro inhibitor Structure
Size Price Availability Quantity
5mg USD 406  USD406 In stock
10mg USD 581  USD581 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

PLpro inhibitor is a potent papain-like protease (PLpro) inhibitor with IC50 of 2.6 μM. PLpro inhibitor shows significant antiviral activity with EC50 values of 13.1 μM, without toxicity up to the highest concentration tested.

Chemical Information
Molecular Weight 346.42
Formula C22H22N2O2
CAS Number 1093070-14-4
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Brendan T Freitas, et al. ACS Infect Dis. Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease

[2] Kiira Ratia, et al. Proc Natl Acad Sci U S A. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

Related Anti-infection Products

LAH4 TFA, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 TFA possesses high plasmid DNA delivery capacities. LAH4 TFA has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes.

Aflatoxin B1

Aflatoxin B1 (AFB1) is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation.


FR901379 is an antifungal lipopeptide.

Rezafungin acetate

Rezafungin acetate is a novel echinocandin-based antifungal agent with potent antifungal activity against Candida, Aspergillus and Pneumocystis.

Epimedokoreanin B

Epimedokoreanin B is a natural flavonoid, which inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B has anticancer, anti-inflammatory and antibacterial activity.

Abmole Inhibitor Catalog

Keywords: PLpro inhibitor supplier, Anti-infection, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.