Free shipping on all orders over $ 500

PLpro inhibitor

Cat. No. M9641
PLpro inhibitor Structure
Size Price Availability Quantity
5mg USD 406  USD406 In stock
10mg USD 581  USD581 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

PLpro inhibitor is a potent papain-like protease (PLpro) inhibitor with IC50 of 2.6 μM. PLpro inhibitor shows significant antiviral activity with EC50 values of 13.1 μM, without toxicity up to the highest concentration tested.

Chemical Information
Molecular Weight 346.42
Formula C22H22N2O2
CAS Number 1093070-14-4
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Brendan T Freitas, et al. ACS Infect Dis. Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease

[2] Kiira Ratia, et al. Proc Natl Acad Sci U S A. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

Related Anti-infection Products
Sulfogaiacol

Sulfogaiacol is a antitussive agent. Sulfogaiacol is used for acute respiratory tract infections, cough and other conditions.

2,4-Dichlorobenzyl alcohol

2,4-Dichlorobenzyl alcohol is a mild antiseptic, with a broad spectrum for bacterial and virus associated with mouth and throat infections.

1,2,3,4-Tetrahydronorharman-1-one

1,2,3,4-Tetrahydronorharman-1-one is a manzamine alkaloid with activity against infectious and tropical parasitic diseases from an Indonesian sponge.

Acetylalkannin

Acetylalkannin (Alkannin acetate) is an isohexenylnaphthazarin pigment isolated from Arnebia euchroma with antimicrobial and cytotoxic activities.

Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R)

Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R), a chimeric peptide consisting of 29 amino acids, is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein).

  Catalog
Abmole Inhibitor Catalog




Keywords: PLpro inhibitor supplier, Anti-infection, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.