Phenothrin, also called sumithrin, is a synthetic pyrethroid that kills adult fleas and ticks.
 |
Source | PLoS One (2015). Figure 1. Phenothrin |
| Method | Insecticide Sensitivity | |
| Cell Lines | Honey Bee Stocks | |
| Concentrations | 0.5 ug/bee | |
| Incubation Time | 24 h | |
| Results | Phenothrin sensitivity significantly decreased by 1.7-, 1.8-, and 2.1-fold in 14-, 28-, and 42-dayold bees, respectively, compared to 3-day-old bees. The decrease in phenothrin sensitivity was significantly correlated with age |
| Cell Experiment | |
|---|---|
| Cell lines | HepG2 cell |
| Preparation method | The cells were exposed to increasing doses of phenothrin (20, 50, 100, 1000 μM) in the corresponding cell-culture medium. The stock solution and the dilution series (100 μM, 10 μM, 1 μM) were made in methanol. Aliquots of different concentrations of phenothrin solution or solvent control were added to the cell cultures and incubated for 1 h at 37°C. The methanol content in the cell culture fluid was 10% (v/v) for each treatment, the concentration found to be non-genotoxic and non-cytotoxic in our previous experiments (unpublished). |
| Concentrations | 20, 50, 100, 1000 μM |
| Incubation time | 1 h |
| Animal Experiment | |
|---|---|
| Animal models | Crj:CD(SD)IGS rats |
| Formulation | |
| Dosages | 0, 100, 300 or 1000 mg/kg/d |
| Administration | oral gavage |
| Molecular Weight | 350.45 |
| Formula | C23H26O3 |
| CAS Number | 26002-80-2 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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