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Penicillamine (Cuprimine, Depen) is used as an antirheumatic and as a chelating agent in Wilson’s disease and is a chelating agent recommended for the removal of excess copper in patients with Wilson’s disease. From in vitro studies which indicate that one atom of copper combines with two molecules of penicillamine. Penicillamine also reduces excess cystine excretion in cystinuria. The mechanism of action of penicillamine in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, penicillamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, penicillamine in vitro depresses T-cell activity but not B-cell activity.
| Molecular Weight | 149.21 |
| Formula | C5H11NO2S |
| CAS Number | 52-67-5 |
| Solubility (25°C) | Water 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] R Munro, et al. Penicillamine
[2] A Bialy-Golan, et al. Penicillamine-induced bullous dermatoses
| Related Cuproptosis Products |
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| Cu(II)-Elesclomol
Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol. Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. |
| DL-Penicillamine
DL-Penicillamine is a copper chelating agent. DL-Penicillamine can cause pyridoxine deficiency and then induce optic axial neuritis. DL-Penicillamine can also depress primary immune response. |
| UM4118
UM4118 is a copper ionophore which can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research. |
| Ammonium tetrathiomolybdate
Ammonium tetrathiomolybdate is a copper chelator and also is a class of sulfide donor. Ammonium tetrathiomolybdate has neuroprotection effects. Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. |
| 2,2'-Bipyridine
2,2'-Bipyridine has been used in the preparation of copper(II)-bipyridine-naringenin complexes. It can be used for the preparation of 2,2'-bipyridine hydrobromide. 2,2'-Bipyridine has good redox stability and glucose elevating activity. |
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