Free shipping on all orders over $ 500

Zinc Pyrithione

Cat. No. M3137
Zinc Pyrithione Structure
Size Price Availability Quantity
500mg USD 45  USD45 In stock
1g USD 60  USD60 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Zinc Pyrithione is an anti-fungal and anti-bacterial drug that disrupts membrane transport by blocking proton pumps and is a potent copper ion carrier that can be used in copper death (cuproptosis) studies.

Chemical Information
Molecular Weight 317.7
Formula C10H8N2O2S2Zn
CAS Number 13463-41-7
Solubility (25°C) DMSO 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sean E Mangion, et al. Targeted Delivery of Zinc Pyrithione to Skin Epithelia

[2] Cheryl Leong, et al. Effect of zinc pyrithione shampoo treatment on skin commensal Malassezia

[3] James R Schwartz. Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics

[4] Mrinal Gupta, et al. Zinc therapy in dermatology: a review

[5] Eugene Guthery, et al. Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects

Related Cuproptosis Products
8-Hydroxyquinoline

8-hydroxyquinoline is a mono-proton bicyclic chelator that is used as a preservative, disinfectant, and insecticide and as a transcription inhibitor. It is a preservative with mild fungal, bacterial, repellent and amoeba killing properties. It is a strong copper ion-carrier and can be used in copper death (Cuproptosis) research.

NSC 319726

NSC 319726 is a p53(R175) mutant activator that inhibits the growth of p53(R175) mutant cells and acts on p53(R175) mutant cells with IC50 of 8 nM, which has no inhibition on p53 wild-type cells. NSC 319726 is a potent copper ion-carrier that can be used in cuproptosis studies.

Elesclomol

Elesclomol (STA-4783) is a novel oxidative stress inducer that acts on tumor cells and promotes their apoptosis, and is a strong copper ion-carrier that can be used for cuproptosis studies.

  Catalog
Abmole Inhibitor Catalog




Keywords: Zinc Pyrithione supplier, Cuproptosis, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.