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Zinc Pyrithione

Cat. No. M3137
Zinc Pyrithione Structure
Size Price Availability Quantity
500mg USD 45  USD45 In stock
1g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Zinc Pyrithione is an anti-fungal and anti-bacterial drug that disrupts membrane transport by blocking proton pumps and is a potent copper ion carrier that can be used in copper death (cuproptosis) studies.

Chemical Information
Molecular Weight 317.7
Formula C10H8N2O2S2Zn
CAS Number 13463-41-7
Solubility (25°C) DMSO 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Sean E Mangion, et al. Targeted Delivery of Zinc Pyrithione to Skin Epithelia

[2] Cheryl Leong, et al. Effect of zinc pyrithione shampoo treatment on skin commensal Malassezia

[3] James R Schwartz. Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics

[4] Mrinal Gupta, et al. Zinc therapy in dermatology: a review

[5] Eugene Guthery, et al. Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects

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Keywords: Zinc Pyrithione supplier, Cuproptosis, inhibitors, activators

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