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Zinc Pyrithione

Cat. No. M3137
Zinc Pyrithione Structure
Size Price Availability Quantity
1g USD 80  USD80 In stock
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Quality Control
  • Current batch:
  • Purity >97%
  • COA
  • MSDS
Biological Activity

Zinc Pyrithione is an anti-fungal and anti-bacterial drug that disrupts membrane transport by blocking proton pumps and is a potent copper ion carrier that can be used in copper death (cuproptosis) studies.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 317.7
Formula C10H8N2O2S2Zn
CAS Number 13463-41-7
Purity >97%
Solubility DMSO 20 mg/mL
Storage at -20°C
References

[1] Sean E Mangion, et al. Targeted Delivery of Zinc Pyrithione to Skin Epithelia

[2] Cheryl Leong, et al. Effect of zinc pyrithione shampoo treatment on skin commensal Malassezia

[3] James R Schwartz. Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics

[4] Mrinal Gupta, et al. Zinc therapy in dermatology: a review

[5] Eugene Guthery, et al. Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects

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Keywords: Zinc Pyrithione supplier, Cuproptosis, inhibitors

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