Free shipping on all orders over $ 500

Elesclomol

Cat. No. M2083
Elesclomol Structure
Synonym:

STA-4783

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
2mg USD 40  USD40 In stock
5mg USD 56  USD56 In stock
10mg USD 90  USD90 In stock
50mg USD 185  USD185 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Elesclomol (STA-4783) is a novel oxidative stress inducer that acts on tumor cells and promotes their apoptosis, and is a strong copper ion carrier that can be used for copper death research. By Affymetrix microarray analysis, Elesclomol significantly induced the expression of heat shock stress response genes and metallothionein genes in Hs294T cells treated at 100 nM for 6 h. Ramos Burkitt's lymphoma B cells were treated with Elesclomol (100 nM) for 1 h and 6 h, respectively, and the Hsp70 RNA level was rapidly increased by 4.8 times and 160 times, which was consistent with the intracellular ROS content. After 0.5 h and 6 h Elesclomol treatment, ROS content increased by 20% and 385%, respectively. Antioxidant N-acetylcysteine (NAC) and Tiron pretreatment could inhibit the induction of Hsp70. HSB2 cells treated with 200 nM Elesclomol for 18 h could induce oxidative stress and increase the apoptotic cells in early stage and late stage by 3.7 times and 11 times, respectively. The above effects could be completely inhibited by NAC, but had no effect on normal cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 400.52
Formula C19H20N4O2S2
CAS Number 488832-69-5
Purity 98.83%
Solubility DMSO 40 mg/mL
Storage at -20°C
References

[1] Blackman RK, et al. PLoS One. Mitochondrial electron transport is the cellular target of the oncology drug elesclomol.

[2] Qu Y, et al. Breast Cancer Res Treat. Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of chemotherapy drugs in breast cancer cells.

[3] Kirshner JR, et al. Mol Cancer Ther. Elesclomol induces cancer cell apoptosis through oxidative stress.

Related Cuproptosis Products
8-Hydroxyquinoline

8-hydroxyquinoline is a mono-proton bicyclic chelator that is used as a preservative, disinfectant, and insecticide and as a transcription inhibitor. Is a kind of antiseptic with mild inhibition of fungi, bacteria, insect repellent, killing amoeba characteristics, is a strong copper ion carrier, can be used for copper death research.

Disulfiram

Disulfiram is used in the study of chronic alcoholism with acute sensitivity to alcohol and is a potent copper ion-carrier that can be used in the study of copper death.

Zinc Pyrithione

Zinc Pyrithione is an anti-fungal and anti-bacterial drug that disrupts membrane transport by blocking proton pumps and is a potent copper ion carrier that can be used in copper death studies.

NSC 319726

NSC 319726 is a p53(R175) mutant activator that inhibits the growth of cells expressing mutant p53. It acts on p53(R175) mutant with IC50 of 8 nM and has no inhibition on p53 wild-type cells. It is a powerful copper ion-carrier and can be used for the study of copper death.

  Catalog
Abmole Inhibitor Catalog




Keywords: Elesclomol, STA-4783 supplier, Cuproptosis, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.