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Paquinimod

Cat. No. M9560

All AbMole products are for research use only, cannot be used for human consumption.

Paquinimod Structure
Synonym:

ABR 25757

Size Price Availability Quantity
10mM*1mL in DMSO USD 90  USD90 In stock
5mg USD 80  USD80 In stock
10mg USD 135  USD135 In stock
25mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. S100A9 is a calcium-binding protein of the S100 family. Paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

Chemical Information
Molecular Weight 350.41
Formula C21H22N2O3
CAS Number 248282-01-1
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jong-Uk Lee, et al. Inhibitory Effect of Paquinimod on a Murine Model of Neutrophilic Asthma Induced by Ovalbumin with Complete Freund's Adjuvant

[2] Qirui Guo, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

[3] Sahar Tahvili, et al. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse

[4] Martin Stenstrm, et al. Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis

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Keywords: Paquinimod, ABR 25757 supplier, inhibitors, activators

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