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Paquinimod

Cat. No. M9560

All AbMole products are for research use only, cannot be used for human consumption.

Paquinimod Structure
Synonym:

ABR 25757

Size Price Availability Quantity
10mM*1mL in DMSO USD 99  USD99 In stock
5mg USD 90  USD90 In stock
10mg USD 145  USD145 In stock
50mg USD 440  USD440 In stock
100mg USD 740  USD740 In stock
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Quality Control & Documentation
Biological Activity

Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. S100A9 is a calcium-binding protein of the S100 family. Paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

Chemical Information
Molecular Weight 350.41
Formula C21H22N2O3
CAS Number 248282-01-1
Solubility (25°C) DMSO ≥ 72 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Roger Hesselstrand, et al. An open-label study to evaluate biomarkers and safety in systemic sclerosis patients treated with paquinimod

[2] Jong-Uk Lee, et al. Inhibitory Effect of Paquinimod on a Murine Model of Neutrophilic Asthma Induced by Ovalbumin with Complete Freund's Adjuvant

[3] Qirui Guo, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

[4] Sahar Tahvili, et al. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse

[5] Martin Stenstrm, et al. Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis

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Keywords: Paquinimod, ABR 25757 supplier, inhibitors, activators

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