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PAOPA 

Cat. No. M27836

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PAOPA  Structure

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Quality Control & Documentation
Biological Activity

PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of Dopamine D2 Receptor. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine D2 receptor and promotes its binding to agonists.

Chemical Information
Molecular Weight 254.29
Formula C11H18N4O3
CAS Number 114200-31-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Ritesh Daya, et al. Curr Mol Pharmacol. The Effect of PAOPA, a Novel Allosteric Modulator of Dopamine D2 Receptors, on Signaling Proteins Following Sub-Chronic Administration in Rats

[2] Ritesh P Daya, et al. Front Behav Neurosci. The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia

[3] Dipannita Basu, et al. PLoS One. Effects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalization

[4] Michael G R Beyaert, et al. Eur Neuropsychopharmacol. PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia

[5] Bailee Dyck, et al. Schizophr Res. PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schi䲧瘀Ỵ瘁

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Keywords: PAOPA  supplier, Dopamine Receptor, inhibitors, activators

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