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Oseltamivir phosphate (Tamiflu) is a competitive neuraminidase inhibitor. The prodrug oseltamivir phosphate (Tamiflu) is itself not virally effective; however, once in the liver, it is converted by natural chemical processes, hydrolysed hepatically to its active metabolite, the free carboxylate of oseltamivir (GS4071). Oseltamivir phosphate (Tamiflu) serves as a competitive inhibitor towards sialic acid, found on the surface proteins of normal host cells. By blocking the activity of the viral neuraminidase enzyme, oseltamivir phosphate (Tamiflu) prevents new viral particles from being released by infected cells. Oseltamivir phosphate (Tamiflu) is an antiviral compound that slows the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell.
| Molecular Weight | 410.4 |
| Formula | C16H28N2O4.H3PO4 |
| CAS Number | 204255-11-8 |
| Solubility (25°C) | Water 50 mg/mL DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Charles W Stratton, et al. Pathogenesis-directed therapy of 2019 novel coronavirus disease
[5] No authors listed. Am J Health Syst Pharm. Oseltamivir phosphate
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