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NSC-87877

Cat. No. M7059
NSC-87877 Structure
Synonym:

NSC87877

Size Price Availability Quantity
10mg USD 100  USD100 In stock
25mg USD 200  USD200 In stock
50mg USD 330  USD330 In stock
100mg USD 560  USD560 In stock
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Quality Control & Documentation
Biological Activity

Nsc-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatase with IC50 values of 0.318 μM and 0.355 μM, respectively. Nsc-87877 also inhibits bispecific phosphatase 26 (DUSP26).

Chemical Information
Molecular Weight 459.45
Formula C19H13N3O7S2
CAS Number 56990-57-9
Form Solid
Solubility (25°C) Water 12 mg/mL (ultrasonic and warming)
DMSO 10 mg/mL (ultrasonic and warming)
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Murayama, et al. ACS Chem Neurosci. SUN11602, a novel aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.

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  Catalog
Abmole Inhibitor Catalog




Keywords: NSC-87877, NSC87877 supplier, Phosphatase, inhibitors, activators


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