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NMD670 is a first-in-class potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM.
NMD670 (20 mg/kg) enhances neuromuscular transmission and restores muscle function in experimental autoimmune myasthenia gravis (MG) rats. NMD670 improves running performance in a passive immunization MG rat model.
| Molecular Weight | 312.12 |
| Formula | C12H10BrNO4 |
| CAS Number | 2354321-33-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Chloride Channel Products |
|---|
| NS1652
NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells. |
| GaTx2
GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. |
| Anthracene-9-carboxylic acid
Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells. |
| T16A(inh)-C01
T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1). T16A(inh)-C01 blocks chloride channel mediated by ANO1 with an IC50 of 8.4 μM, without interfering with calcium signaling. |
| Picrotoxinin
Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. |
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