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CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).
| Molecular Weight | 347.43 |
| Formula | C18H21NO4S |
| CAS Number | 407587-33-1 |
| Solubility (25°C) | DMSO 34.74 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Chloride Channel Products |
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| NS1652
NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells. |
| NMD670
NMD670 is a first-in-class small molecule inhibitor of the skeletal muscle specific chloride ion channel (ClC-1). NMD670 improves skeletal muscle function in rat models with myasthenia gravis. |
| GaTx2
GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. |
| Anthracene-9-carboxylic acid
Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells. |
| T16A(inh)-C01
T16A(inh)-C01 is an inhibitor of TMEM16A (ANO1). T16A(inh)-C01 blocks chloride channel mediated by ANO1 with an IC50 of 8.4 μM, without interfering with calcium signaling. |
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