Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders.
Molecular Weight | 472.57 |
Formula | C27H36O7 |
CAS Number | 86401-95-8 |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Antonio Torrelo. Int J Dermatol. Methylprednisolone aceponate for atopic dermatitis
Related GCR Products |
---|
ORIC-101
ORIC-101 is a potent and selective glucocorticoid receptor antagonist with an EC50 value of 5.6 nM and anticancer activity. |
Mometasone Furoate Monohydrate
Mometasone Furoate Monohydrate is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. |
RU 26988
RU 26988 is a highly specific glucocorticoid receptor agonist. |
HP210
HP210 is a selective glucocorticoid receptor modulator (SGRM). |
Glucocorticoid receptor modulator 2
Glucocorticoid receptor modulator 2 is a glucocorticoid receptor modulator, with an IC50 value less than 100 nM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.