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Budesonide

Cat. No. M2245
Budesonide Structure
Synonym:

Rhinocort; Pulmicort

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 40  USD40 In stock
100mg USD 55  USD55 In stock
200mg USD 95  USD95 In stock
500mg USD 230  USD230 In stock
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Quality Control & Documentation
Biological Activity

Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis. Budesonide reverses DNA hypomethylation and modulates expression of cancer related genes. Budesonide prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration.

Chemical Information
Molecular Weight 430.53
Formula C25H34O6
CAS Number 51333-22-3
Solubility (25°C) DMSO 86 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Paul M O'Byrne, et al. Effect of a single day of increased as-needed budesonide-formoterol use on short-term risk of severe exacerbations in patients with mild asthma: a post-hoc analysis of the SYGMA 1 study

[2] Donald P Tashkin, et al. Benefit:Risk Profile of Budesonide in Obstructive Airways Disease

[3] Antonio Lpez-Sanromn, et al. Reviewing the therapeutic role of budesonide in Crohn's disease

[4] Gary R Lichtenstein. Budesonide Multi-matrix for the Treatment of Patients with Ulcerative Colitis

[5] Staffan Edsbcker, et al. Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease

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Keywords: Budesonide, Rhinocort; Pulmicort supplier, GCR, inhibitors, activators


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