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Melitracen hydrochloride

Cat. No. M20447
Melitracen hydrochloride Structure
Synonym:

Thymeol hydrochloride

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Melitracen hydrochloride is a potential dopamine D1/2 receptor antagonist which has antidepressant properties.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 327.89
Formula C21H26ClN
CAS Number 10563-70-9
Purity >99%
Solubility DMSO 65 mg/mL
Water 65 mg/mL
Storage at -20°C
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