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Melitracen hydrochloride

Cat. No. M20447
Melitracen hydrochloride Structure

Thymeol hydrochloride

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Biological Activity

Melitracen hydrochloride is a potential dopamine D1/2 receptor antagonist which has antidepressant properties.

Chemical Information
Molecular Weight 327.89
Formula C21H26ClN
CAS Number 10563-70-9
Solubility (25°C) DMSO 65 mg/mL
Water 65 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Xue Wang, et al. J Tradit Chin Med. Meta-analysis of the clinical effectiveness of combined acupuncture and Western Medicine to treat post-stroke depression

[2] K Shimamoto, et al. Acta Sch Med Univ Kioto. Myriatic effect of 9-(gamma-dimethylamino-propylidene)-10, 10-diemthyl-9, 10-dihydroanthracene hydrochloride (Melitracen) in mice and rats

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Keywords: Melitracen hydrochloride, Thymeol hydrochloride supplier, Dopamine Receptor, inhibitors, activators

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