Melitracen hydrochloride is a potential dopamine D1/2 receptor antagonist which has antidepressant properties.
|Solubility (25°C)||DMSO 65 mg/mL
Water 65 mg/mL
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Dopamine Receptor Products|
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis.
|Ensaculin free base
Ensaculin free base (KA-672) is a NMDA antagonist and have high affinities to serotonergic 5-HT1A and 5-HT7 receptors, adrenergic α1, and dopaminergic D2 and D3 receptors.
NPEC-caged-dopamine is a caged version of dopamine.
D4R agonist-1 is a D4R partial agonist (Ki: 2.2 nM).
SKF 83822 is an atypical agonist of dopamine D1 receptor.
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