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GBR-12879 dihydrochloride

Cat. No. M41811
GBR-12879 dihydrochloride Structure
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Biological Activity

GBR-12879 dihydrochloride is a potent inhibitor of dopamine uptake.

Chemical Information
Molecular Weight 521.47
Formula C28H32Cl2F2N2O
CAS Number 67469-45-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tianlu Li et al. Methods Mol Biol. Sulfated Glycoprotein Synthesis

[2] Jonathan Wolf Mueller et al. J Clin Endocrinol Metab. Steroid Sulfation in Adrenal Tumors

[3] Thomas Alec Lightning et al. Mol Cell Endocrinol. Steroid disulfates - Sulfation double trouble

[4] Süleyman Günal et al. J Biol Chem. Sulfation pathways from red to green

[5] Christine Kaufmann et al. J Exp Bot. Sulfated plant peptide hormones

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