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Fosinopril Sodium

Cat. No. M5664
Fosinopril Sodium Structure
Synonym:

SQ28555

Size Price Availability Quantity
50mg USD 90  USD90 In stock
100mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

Chemical Information
Molecular Weight 585.64
Formula C30H45NO7P.Na
CAS Number 88889-14-9
Form Solid
Solubility (25°C) 117 mg/mL in water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Huang ZB, et al. Naunyn Schmiedebergs Arch Pharmacol. Fosinopril improves the electrophysiological characteristics of left ventricular hypertrophic myocardium in spontaneously hypertensive rats.

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Keywords: Fosinopril Sodium, SQ28555 supplier, ACE, inhibitors, activators


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