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FA-Phe-Phe

Cat. No. M42286
FA-Phe-Phe Structure
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Biological Activity

FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE).

Chemical Information
Molecular Weight 432.47
Formula C25H24N2O5
CAS Number 83661-95-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gabriela Niemirowicz et al. Biochem J. Two metallocarboxypeptidases from the protozoan Trypanosoma cruzi belong to the M32 family, found so far only in prokaryotes

[2] M Mayer et al. J Med Chem. Mapping the active site of angiotensin-converting enzyme by transferred NOE spectroscopy

[3] H Ostrowska et al. Biochem Biophys Res Commun. Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme

[4] A V Pshezhetsky et al. Anal Biochem. Continuous spectrophotometric assay of human lysosomal cathepsin A/protective protein in normal and galactosialidosis cells

[5] R Shapiro et al. Biochemistry. Inhibition of angiotensin converting enzyme: mechanism and substrate dependence

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