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Dihydrexidine

Cat. No. M27996

All AbMole products are for research use only, cannot be used for human consumption.

Dihydrexidine Structure
Synonym:

DAR-0100

Price and Availability

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Quality Control & Documentation
Biological Activity

Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity. Dihydrexidine can stimulate YAP phosphorylation.

Chemical Information
Molecular Weight 267.32
Formula C17H17NO2
CAS Number 123039-93-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Suzane Rosa da Silva, et al. Amino Acids. Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues

[2] Andrew J Haak, et al. Sci Transl Med. Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

[3] Peter Salmi, et al. CNS Drug Rev. Dihydrexidine--the first full dopamine D1 receptor agonist

[4] T D Steele, et al. Pharmacol Biochem Behav. D1 agonist dihydrexidine releases acetylcholine and improves cognitive performance in rats

[5] B J Johnson, et al. Pharmacol Biochem Behav. Dihydrexidine, a full D1 dopamine receptor agonist, induces rotational asymmetry in hemiparkinsonian monkeys

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Keywords: Dihydrexidine, DAR-0100 supplier, Dopamine Receptor, inhibitors, activators

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