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Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. Target: Glucocorticoid Receptor Desonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses. Desonide induced significant colorimetric improvement compared with placebo. A good to excellent response was achieved in 30% for desonide, and 6% for placebo. Decreased pigmentation in the desonide-treated axillae was associated with recovery of disruption at the basal membrane. Desonide showed depigmenting properties in women with axillary hyperpigmentation. Given the favorable safety profile of all other desonide preparations and their utility as a low potency corticosteroid, desonide foam promises to be a useful addition to the armamentarium, when other desonide vehicles might be less acceptable.
| Molecular Weight | 416.51 |
| CAS Number | 638-94-8 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] No authors listed. Desonide
[2] Nr Kahanek, et al. Desonide: a review of formulations, efficacy and safety
[3] Daniel Parish, et al. Desonide foam: a review
[4] Noah S Scheinfeld, et al. Desonide gel
[5] Vicky Kwan Wong, et al. Overview on desonide 0.05%: a clinical safety profile
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