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Chlorhexidine

Cat. No. M9694
Chlorhexidine Structure
Size Price Availability Quantity
100mg USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Chlorhexidine is a disinfectant and topical anti-infective agent. Chlorhexidine is used to clean the skin after an injury, before surgery, or before an injection. Chlorhexidine gluconate (ip) reduces postoperative intra-abdominal infection in mice at the end of colon surgery.

Chemical Information
Molecular Weight 505.45
Formula C22H30Cl2N10
CAS Number 55-56-1
Solubility (25°C) DMSO ≥ 21 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wael E Shams, et al. J Surg Res. Peritoneal lavage using chlorhexidine gluconate at the end of colon surgery reduces postoperative intra-abdominal infection in mice

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