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BI 653048 

Cat. No. M27921

All AbMole products are for research use only, cannot be used for human consumption.

BI 653048  Structure

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Quality Control & Documentation
Biological Activity

BI 653048 is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM). BI 653048 is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus.

Chemical Information
Molecular Weight 515.52
Formula C23H25F4N3O4S
CAS Number 1198784-72-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Christian Harcken, et al. Expert Opin Investig Drugs. Clinical profile of the functionally selective glucocorticoid receptor agonist BI 653048 in healthy male subjects

[2] Johann Bartko, et al. Pharmacol Res. Selective glucocorticoid receptor modulation inhibits cytokine responses in a canine model of mild endotoxemia

[3] Nicholas W Mszar, et al. Angew Chem Int Ed Engl. Electronically Activated Organoboron Catalysts for Enantioselective Propargyl Addition to Trifluoromethyl Ketones

[4] Daniel R Fandrick, et al. J Org Chem. Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate

[5] Jonathan T Reeves, et al. J Org Chem. Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4

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Keywords: BI 653048  supplier, GCR, inhibitors, activators

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