BI 653048 is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM). BI 653048 is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus.
Molecular Weight | 515.52 |
Formula | C23H25F4N3O4S |
CAS Number | 1198784-72-3 |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related GCR Products |
---|
ORIC-101
ORIC-101 is a potent and selective glucocorticoid receptor antagonist with an EC50 value of 5.6 nM and anticancer activity. |
Mometasone Furoate Monohydrate
Mometasone Furoate Monohydrate is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. |
RU 26988
RU 26988 is a highly specific glucocorticoid receptor agonist. |
HP210
HP210 is a selective glucocorticoid receptor modulator (SGRM). |
Glucocorticoid receptor modulator 2
Glucocorticoid receptor modulator 2 is a glucocorticoid receptor modulator, with an IC50 value less than 100 nM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.