All AbMole products are for research use only, cannot be used for human consumption.
BI-0474 is a covalent KRASG12C inhibitor. The IC50 value for GDP-KRAS::SOS1 protein-protein interaction was 7.0 nM. BI-0474 also showed better antitumor activity in non-small cell lung cancer xenograft models.
| Molecular Weight | 587.74 |
| Formula | C30H37N9O2S |
| CAS Number | 2750570-55-7 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Ras Products |
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| HH0043
HH0043 is an orally active and potent SOS1 inhibitor, with IC50 value of 5.8 nM. |
| BI-2493
BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. |
| D3S-001
D3S-001 is an orally active inhibitor for KRAS. |
| MK-1084
MK-1084 is a selective KRAS G12C inhibitor. |
| ADT-007
ADT-007 is a potent and orally active pan-RAS inhibitor with strong anticancer effects. |
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