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ASP2151 (also known as ASP2151) had significantly better anti-HSV activity against herpes simplex keratitis than valacyclovir and acyclovir after systemic or topical use. Amenamevir against HSV-1 and HSV-2 with EC50s of 14 (range, 7.7 to 20) and 30 ng/mL (range, 15 to 58), respectively.
In vivo, Amenamevir treatment decreases both lesion scores and HSV-1 titers in a dose-dependent manner, irrespective of the dosing interval. Amenamevir (ASP2151) administration accelerates the reduction in virus titer in a dose-dependent manner in the range of 3 to 30 mg/kg/day.
| Molecular Weight | 482.55 |
| Formula | C24H26N4O5S |
| CAS Number | 841301-32-4 |
| Solubility (25°C) | DMSO: ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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