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5MPN

Cat. No. M45095

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5MPN Structure
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Biological Activity

5MPN is a first-in-class, orally active and selective inhibitor of fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4), which does not inhibit PFK-1 or PFKFB3. 5MPN is a competitive inhibitor of the F6P-binding site (Ki=8.6 μM). 5MPN inhibits proliferation of various cancer cell lines by targeting tumor glucose metabolism. 5MPN is a competitive inhibitor of the F6P binding site (Ki=8.6 μM). 5MPN can inhibit the proliferation of various cancer cell lines by targeting tumor glycolysis.

Chemical Information
Molecular Weight 305.33
Formula C15H19N3O4
CAS Number 47208-82-2
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Seiichi Okabe, et al. Biomark Res. Therapeutic targeting of PFKFB3 and PFKFB4 in multiple myeloma cells under hypoxic conditions

[2] Dan Li, et al. J Cancer. PFKFB4 promotes angiogenesis via IL-6/STAT5A/P-STAT5 signaling in breast cancer

[3] Ruifang Gao, et al. Theranostics. CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism

[4] Jason Chesney, et al. Oncotarget. Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor

[5] Cristina Ortega, et al. Mar Pollut Bull. Correlations between microbial indicators, pathogens, and environmental factors in a subtropical estuary

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Keywords: 5MPN supplier, Phosphatase, inhibitors, activators

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