| Cat.No. | Name | Information |
|---|---|---|
| M29189 | Uzansertib phosphate | Uzansertib (INCB053914) phosphate is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines. |
| M28699 | Uzansertib | Uzansertib (INCB053914) is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib has broad anti-proliferative activity against a variety of hematologic tumor cell lines. |
| M27950 | PIM447 | PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis. |
| M20362 | WAY-301464 | WAY-301464 is a Pim-1 inhibitor. |
| M20347 | WAY-312187 | WAY-312187 is a Pim-1 kinase inhibitor. |
| M20156 | WAY-349807 | WAY-349807 is a PIM-1 kinase inhibitor. |
| M20155 | WAY-349290 | WAY-349290 can inhibit the activity of Pim kinases |
| M20056 | WAY-278535 | WAY-278535 is a inhibitor of Pim-1 and/or Pim-2 protein kinase |
| M20055 | WAY-278534 | WAY-278534 is a inhibitor of Pim-1 and/or Pim-2 protein kinase |
| M20051 | WAY-272589 | WAY-272589 is a Pin1 ligand. |
| M14145 | PIM-447 dihydrochloride | PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. |
| M14144 | GDC-0339 | GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma. |
| M13428 | SEL24-B489 | Sel24-b489 is a novel pan-PIM inhibitor that induces apoptosis in DLBCL cell lines at low/submicromol concentrations and has shown activity in xenotransplantation models. It is an effective oral PIM and FLT3-ITD dual inhibitor with Kds of 2, 2 and 3 nM against PIM1, PIM2 and PIM3, respectively. |
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