Free shipping on all orders over $ 500

GDC-0339

Cat. No. M14144

All AbMole products are for research use only, cannot be used for human consumption.

GDC-0339 Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma.

Chemical Information
Molecular Weight 465.5
CAS Number 1428569-85-0
Solubility (25°C) DMSO ≥ 52 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Aaron G Bart, et al. Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate

[2] Xiaojing Wang, et al. Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

[3] Ryan H Takahashi, et al. CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339

Related Pim Products
10-DEBC 

10-DEBC is a selective Akt inhibitor.

R8-T198wt

R8-T198wt is a cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase.

FD1024

FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3).

Pim-1 kinase inhibitor 5

Pim-1 kinase inhibitor 5 is a Pim-1 kinase inhibitor (IC50: 0.61 μM).

Pim-1 kinase inhibitor 4

Pim-1 kinase inhibitor 4 is a Pim-1 kinase inhibitor (IC50: 17.01 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: GDC-0339 supplier, Pim, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.