About 30 results found for searched term "Pim" (0.01 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1652 | AS703026 | MEK |
| MSC1936369B,Pimasertib | ||
| AS703026 is a novel selective MEK1/2 inhibitor, and induces pleiotropic anti-myeloma activity in vitro and in vivo. | ||
| M1675 | BIRB796 | p38 MAPK |
| Doramapimod | ||
| BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK with Kd of 100pM. | ||
| M1781 | Adezmapimod (SB203580) | p38 MAPK |
| RWJ 64809; PB 203580; Adezmapimod | ||
| Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. | ||
| M1958 | Natamycin | Antibiotic |
| Natacyn; Pimaricin | ||
| Natamycin is an antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. | ||
| M2221 | Pimecrolimus | Immunology/Inflammation |
| Elidel | ||
| Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis. | ||
| M2320 | 17-AAG (Tanespimycin) | HSP |
| Tanespimycin; 17AAG; NSC 330507; CP 127374 | ||
| 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM. | ||
| M2321 | 17-DMAG (Alvespimycin) hydrochloride | HSP |
| Alvespimycin, NSC 707545 | ||
| 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) hydrochloride is a potent HSP90 inhibitor with IC50 of 62 nM. | ||
| M2572 | SMI-4a | Pim |
| TCS PIM-1 4a; 327033-36-3 | ||
| SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modest potent to Pim-2, does not significantly inhibit other serine/threonine- or tyrosine-kinases. | ||
| M2777 | IPI-504 hydrochloride | HSP |
| Retaspimycin hydrochloride; IPI-504 hcl | ||
| IPI-504 (Retaspimycin) hydrochloride is a potent inhibitor of HSP90 with EC50 of 63 nM. | ||
| M2945 | Pimozide | Dopamine Receptor |
| R6238 | ||
| Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M3294 | VX-745 | p38 MAPK |
| Neflamapimod | ||
| VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ. | ||
| M3434 | Pimobendan | PDE |
| pimobendane | ||
| Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. | ||
| M3659 | Pimavanserin | 5-HT Receptor |
| ACP-103 | ||
| Pimavanserin is a selective serotonin 5-HT2A inverse agonist, with pIC50 and pKd of 8.73 and 9.3, respectively. | ||
| M3683 | Retaspimycin | HSP |
| IPI-504 | ||
| Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). | ||
| M3745 | TCS PIM-1 1 | Pim |
| SC 204330 | ||
| TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s > 20,000 nM). | ||
| M3751 | Losmapimod | p38 MAPK |
| GW-856553X; GSK-AHAB; SB856553 | ||
| Losmapimod (GW856553) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. | ||
| M8991 | Dilmapimod | p38 MAPK |
| SB-681323; GW-681323 | ||
| Dilmapimod (also known as SB-681323 and GW-681323) is a p38 MAPK inhibitor that potentially suppresses inflammation in COPD. | ||
| M4200 | Epimedin-A | Others |
| Epimedin A is A natural compound extracted from epimedium. | ||
| M4201 | Epimedin-B | Others |
| Epimedin B, a natural active ingredient in Epimedium, is reported to have anti-osteoporosis potential. | ||
| M4202 | Epimedin-C | Others |
| Epimedin-C; Baohuoside-VI | ||
| Epmedin C is a natural compound with estrogen-like effects in ovariectomized mice. | ||
| M4203 | Epimedin-A1 | Others |
| Hexandraside F | ||
| Epimedin A1 is a flavonoid extracted from epimedium. | ||
| M4205 | Epimedoside-A | Others |
| Epimedoside A is A flavonoid isolated from the roots of Epimedium Wushanense. Epimedoside A has significant antioxidant activity in vitro. | ||
| M5387 | Acipimox | Others |
| Olbemox，K-9321 | ||
| Acipimox (K-9321) is a nicotinic acid analogue with anti-lipid and anti-lipolysis effects. Acipimox can acutely inhibit lipolysis, inhibit free fat levels throughout the body and improve insulin sensitivity. | ||
| M5408 | Aminoguanidine hydrochloride | NO Synthase |
| Pimagedine; GER-11; Guanyl hydrazine; Hydrazinecarboximidamide | ||
| Aminoguanidine hydrochloride is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone. | ||
| M5488 | Cefepime Dihydrochloride Monohydrate | Antibiotic |
| Cefepime Dihydrochloride Monohydrate is a broad-spectrum cephalosporin with enhanced coverage against Gram-positive and Gram-negative bacteria. | ||
| M7140 | PIM-1 Inhibitor 2 | Others |
| PIM-1 Inhibitor 2 is a pim-1 kinase inhibitor. | ||
| M7249 | SB 203580 hydrochloride | p38 MAPK |
| Adezmapimod hydrochloride ; RWJ 64809 hydrochloride | ||
| SB 203580 hydrochloride is a selective inhibitor of p38 MAPK; water-soluble. | ||
| M7374 | TC-H 106 | HDAC |
| Pimelic Diphenylamide 106; RGFA-8; Histone Deacetylase Inhibitor VII | ||
| TC-H 106 is a class I histone deacetylase inhibitor, with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively. | ||
| M7945 | Pimonidazole | Others |
| Pimonidazole is an effective and nontoxic exogenous 2-nitroimidazole hypoxia marker. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia. | ||
| M8515 | Nifetepimine | Others |
| Nifetepimine is a dihydropyrimidone calcium channel blocker that down-modulates SERCA3 (sarco/endoplasmic reticulum Ca2+ -ATPase 3) pump, and protects of the CD4+ T cells from tumor-induced apoptosis. | ||
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