About 30 results found for searched term "Pim" (0.011 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1652 | AS703026 | MEK |
| MSC1936369B,Pimasertib | ||
| AS703026 is a novel selective MEK1/2 inhibitor, and induces pleiotropic anti-myeloma activity in vitro and in vivo. | ||
| M1675 | BIRB796 | p38 MAPK |
| Doramapimod | ||
| BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK with Kd of 100pM. | ||
| M1781 | Adezmapimod (SB203580) | p38 MAPK |
| RWJ 64809; PB 203580; Adezmapimod | ||
| Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. | ||
| M1958 | Natamycin | Antibiotic |
| Natacyn; Pimaricin | ||
| Natamycin is an antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. | ||
| M2221 | Pimecrolimus | Immunology/Inflammation |
| Elidel | ||
| Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis. | ||
| M2320 | 17-AAG (Tanespimycin) | HSP |
| Tanespimycin; 17AAG; NSC 330507; CP 127374 | ||
| 17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM. | ||
| M2321 | 17-DMAG (Alvespimycin) hydrochloride | HSP |
| Alvespimycin, NSC 707545 | ||
| 17-DMAG (Alvespimycin, KOS-1022, NSC 707545) hydrochloride is a potent HSP90 inhibitor with IC50 of 62 nM. | ||
| M2572 | SMI-4a | Pim |
| TCS PIM-1 4a | ||
| SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modest potent to Pim-2, does not significantly inhibit other serine/threonine- or tyrosine-kinases. | ||
| M2777 | IPI-504 hydrochloride | HSP |
| Retaspimycin hydrochloride; IPI-504 hcl | ||
| IPI-504 (Retaspimycin) hydrochloride is a potent inhibitor of HSP90 with EC50 of 63 nM. | ||
| M2945 | Pimozide | Dopamine Receptor |
| R6238 | ||
| Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M3294 | VX-745 | p38 MAPK |
| Neflamapimod | ||
| VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ. | ||
| M3434 | Pimobendan | PDE |
| pimobendane | ||
| Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. | ||
| M3659 | Pimavanserin | 5-HT Receptor |
| ACP-103 | ||
| Pimavanserin is a selective serotonin 5-HT2A inverse agonist. | ||
| M3683 | Retaspimycin | HSP |
| IPI-504 | ||
| Retaspimycin is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). | ||
| M3745 | TCS PIM-1 1 | Pim |
| SC 204330 | ||
| TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s > 20,000 nM). | ||
| M3751 | Losmapimod | p38 MAPK |
| GW-856553X; GSK-AHAB; SB856553 | ||
| Losmapimod (GW856553) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. | ||
| M8991 | Dilmapimod | p38 MAPK |
| SB-681323; GW-681323 | ||
| Dilmapimod (also known as SB-681323 and GW-681323) is a p38 MAPK inhibitor that potentially suppresses inflammation in COPD. | ||
| M4200 | Epimedin-A | Others |
| Epimedin A is A natural compound extracted from epimedium. | ||
| M4201 | Epimedin-B | Others |
| Epimedin B, a natural active ingredient in Epimedium, is reported to have anti-osteoporosis potential. | ||
| M4202 | Epimedin-C | Others |
| Epimedin-C; Baohuoside-VI | ||
| Epmedin C is a natural compound with estrogen-like effects in ovariectomized mice. | ||
| M4203 | Epimedin-A1 | Others |
| Hexandraside F | ||
| Epimedin A1 is a flavonoid extracted from epimedium. | ||
| M4205 | Epimedoside-A | Others |
| Epimedoside A is A flavonoid isolated from the roots of Epimedium Wushanense. Epimedoside A has significant antioxidant activity in vitro. | ||
| M5019 | TCS-PIM-1-4a | Pim |
| SMI-4a | ||
| TCS-PIM-1-4a is a Pim inhibitor that blocks mTORC1 activity via activation of AMPK; kills a wide range of both myeloid and lymphoid cell lines (with IC50 values ranging from 0.8 to 40 μM). | ||
| M5387 | Acipimox | Others |
| Olbemox，K-9321 | ||
| Acipimox (K-9321) is a nicotinic acid analogue with anti-lipid and anti-lipolysis effects. Acipimox can acutely inhibit lipolysis, inhibit free fat levels throughout the body and improve insulin sensitivity. | ||
| M5408 | Aminoguanidine hydrochloride | NO Synthase |
| Pimagedine; GER-11; Guanyl hydrazine; Hydrazinecarboximidamide | ||
| Aminoguanidine hydrochloride is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone. | ||
| M5488 | Cefepime Dihydrochloride Monohydrate | Antibiotic |
| Cefepime Dihydrochloride Monohydrate is a broad-spectrum cephalosporin with enhanced coverage against Gram-positive and Gram-negative bacteria. | ||
| M7140 | PIM-1 Inhibitor 2 | Others |
| PIM-1 Inhibitor 2 is a pim-1 kinase inhibitor. | ||
| M7249 | SB 203580 hydrochloride | p38 MAPK |
| Adezmapimod hydrochloride ; RWJ 64809 hydrochloride | ||
| SB 203580 hydrochloride is a selective inhibitor of p38 MAPK; water-soluble. | ||
| M7945 | Pimonidazole | Others |
| Pimonidazole is an effective and nontoxic exogenous 2-nitroimidazole hypoxia marker. | ||
| M8515 | Nifetepimine | Others |
| Nifetepimine is a dihydropyrimidone calcium channel blocker that down-modulates SERCA3 (sarco/endoplasmic reticulum Ca2+ -ATPase 3) pump, and protects of the CD4+ T cells from tumor-induced apoptosis. | ||
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