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Uzansertib (INCB053914) phosphate is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC50s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines.
| Molecular Weight | 611.51 |
| Formula | C26H29F3N5O7P |
| CAS Number | 2088852-47-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL (Need ultrasonic and warming) |
| Storage | 4°C, dry, sealed |
[2] No authors listed. Cold Spring Harb Protoc. Phosphate-Limited Chemostat Medium
[3] Marc G Vervloet, et al. Nat Rev Nephrol. The role of phosphate in kidney disease
[4] Eleanor Lederer. J Physiol. Regulation of serum phosphate
[5] O Susan Iheagwara, et al. Hemodial Int. Phosphorus, phosphorous, and phosphate
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| FD1024
FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). |
| Pim-1 kinase inhibitor 5
Pim-1 kinase inhibitor 5 is a Pim-1 kinase inhibitor (IC50: 0.61 μM). |
| Pim-1 kinase inhibitor 4
Pim-1 kinase inhibitor 4 is a Pim-1 kinase inhibitor (IC50: 17.01 nM). |
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