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SEL24-B489

Cat. No. M13428

All AbMole products are for research use only, cannot be used for human consumption.

SEL24-B489 Structure

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Quality Control & Documentation
Biological Activity

Sel24-b489 is a novel pan-PIM inhibitor that induces apoptosis in DLBCL cell lines at low/submicromol concentrations and has shown activity in xenotransplantation models. It is an effective oral PIM and FLT3-ITD dual inhibitor with Kds of 2, 2 and 3 nM against PIM1, PIM2 and PIM3, respectively.

Chemical Information
Molecular Weight 446.14
Formula C15H18Br2N4O2
CAS Number 1616359-00-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mei Wu, et al. J Hematol Oncol. FLT3 inhibitors in acute myeloid leukemia

[2] Wojciech Czardybon, et al. Oncotarget. A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia

[3] Emilia Białopiotrowicz, et al. J Cell Mol Med. Microenvironment-induced PIM kinases promote CXCR4-triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration

[4] Maciej Szydłowski, et al. Blood. Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma

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  Catalog
Abmole Inhibitor Catalog




Keywords: SEL24-B489 supplier, Pim, inhibitors, activators

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