All AbMole products are for research use only, cannot be used for human consumption.
SGI-1776 is novel small molecule inhibitor of PIM kinase activity with IC50 of 7 ± 1.8, 363 ± 27.6 and 69 ± 9.2 nM for Pim-1, Pim-2, and Pim-3, respectively.SGI-1776 compound is a FLT3 kinase inhibitor and preferentially induces apoptosis in AML cells harboring a FLT3-IT3 mutation.SGI-1776 also exhibited cytotoxic activity in vitro with a median relative IC50 of 3.1μM.
 |
Source | Clin Lymphoma Myeloma Leuk (2013). Figure 2. SGI-1776 |
| Method | Macromolecule synthesis assay | |
| Cell Lines | JeKo-1 cells | |
| Concentrations | 5 μM | |
| Incubation Time | 24 h | |
| Results | With 5μM SGI-1776 alone there was 20% reduction of DNA synthesis level compared to DMSO treated control cells, while 40%-65% reduction of DNA synthesis was induced by 5 and 10μM of bendamustine single treatment in 24hr. |
| Molecular Weight | 405.42 |
| Formula | C20H22F3N5O |
| CAS Number | 1025065-69-3 |
| Solubility (25°C) | DMSO 65 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Pim Products |
|---|
| 10-DEBC
10-DEBC is a selective Akt inhibitor. |
| R8-T198wt
R8-T198wt is a cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase. |
| FD1024
FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). |
| Pim-1 kinase inhibitor 5
Pim-1 kinase inhibitor 5 is a Pim-1 kinase inhibitor (IC50: 0.61 μM). |
| Pim-1 kinase inhibitor 4
Pim-1 kinase inhibitor 4 is a Pim-1 kinase inhibitor (IC50: 17.01 nM). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
