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PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis.
| Molecular Weight | 513.38 |
| CAS Number | 1820565-69-2 |
| Solubility (25°C) | Water 50 mg/mL DMSO ≥ 46.7 mg/mL |
| Storage | 2-8°C, dry, sealed |
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