Certificate of Analysis

 

Product Name: PIM-447 dihydrochloride
Catalog Number: M14145
CAS Number: 1820565-69-2

Physical and Chemical Properties
Molecular Weight: 513.38
Solubility: Water 50 mg/mL; DMSO ≥ 46.7 mg/mL
Storage: 2-8°C, dry, sealed
Chemical Structure: PIM-447 dihydrochloride Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.