| Cat.No. | Name | Information |
|---|---|---|
| M2206 | TH-302 (Evofosfamide) | TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM. |
| M6098 | Baicalein | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor, IC50 value of 3.12 mM. |
| M9325 | EGTA | EGTA is a specific calcium chelator with a Kd of 60.5 nM at physiological pH (7.4) and a high specificity for Ca2+ than for Mg2+.EGTA significantly inhibits the substrate adhesion capacity of inflammatory macrophages. |
| M9330 | Brij-35 | Brij-35 (Polidocanol) is a high HLB, ethoxylated, nonionic ether of lauryl alcohol with broad pH stability. |
| M6154 | 2-PMPA tetrasodium | 2-PMPA (PMPA tetrasodium salt) is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM. |
| M2250 | Pamidronate disodium | Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. |
| M9916 | DPPH | DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that measures the free radical scavenging activity of antioxidants. |
| M9194 | Insulin (human) | Insulin (human) is a polypeptide hormone that regulates the level of sugar (glucose) in the blood and is produced by beta cells of islets. |
| M3409 | Formestane | Formestane is a second generation selective aromatase inhibitor with an IC50 of 80 nM. |
| M9331 | 10-Hydroxy-trans-2-decenoic acid | 10-hydroxy-2-decenoic acid (10-H2DA) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. |
| M10889 | SHP836 | SHP836 is an allosteric inhibitor of SHP2 that inhibits SHP2 IC50 The value is 12 μM. |
| M10888 | SHP394 | SHP394 is a potent, orally active, allosterical selective SHP2 inhibitor,IC50 23 nM. |
| M10887 | SHP389 | SHP389 is an allosteric inhibitor of SHP2, which is anti-SHP2 and p-ERK IC50 The values are all 36 nM. |
| M10884 | s217622 | YH-53 IS AN EFFECTIVE ONE 3CLpro Inhibitor, 3CL against SARS-CoV-1pro and SARS-CoV-2 3CLpro target Ki The values are 6.3 nM and 34.7 nM, respectively. YH-53 strongly blocks SARS-CoV-2 replication. YH-53 is a peptide-mimetic compound with unique benzothiazolidinone. |
| M10882 | RMC-0331 | RMC-0331 (RM-023) is a highly potent, selective, and oral bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation by disrupting RAS-SOS1 interactions. |
| M10881 | ristocetin | |
| M10878 | Reldesemtiv | Reldesemtiv (CK-2127107) is a selective, orally active next-generation rapid skeletal muscle troponin activator (FSTA). Reldesemtiv selectively activates rapid skeletal muscle fibrils, EC50Is 3.4 μM. |
| M10877 | QCA570 | QCA570 is made up of Cereblon ligands and BET ligands connected to PROTAC, which is paired with the BRD4 BD1 protein IC50 The value is 10 nM. |
| M10874 | plocabulin | Pm-060184 is a microtubulin polymerization inhibitor. |
| M10872 | Lufotrelvir | PF-07304814 IS A PHOSPHATE PRODRUG FOR PF-00835231 THAT BINDS AND INHIBITS SARS-CoV-2 3CLpro Active, Ki is 174 nM. |
| M10869 | OP-5244 | OP-5244 is a potent and orally active CD73 inhibitor,IC50 The value is 0.25 nM. OP-5244 reverses the immunosuppressive effect by blocking the production of adenosine, with the potential to conduct cancer research. |
| M10866 | NSC-70220 | NSC-70220 is a selective allosteric SOS1 inhibitor. NSC-70220 inhibits allosteric site activation and partially inhibits catalytic site activation. NSC-70220 has anti-cancer effects. |
| M10864 | Nicodicosapent | Nicodicosapent is a fatty acid niacin conjugate that inhibits the activity of sterol regulatory element binding proteins (SREBP) and the activity of proteins that regulate cholesterol metabolism such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1. |
| M10863 | NCGC00378430 | NCGC00378430 is a potent inhibitor of the SIX1/EYA2 interaction. NCGC00378430 partially reverses SIX1 overexpression-mediated transcription and metabolic profiling, and reverses SIX1-induced TGF-β signaling and epithelial-interstitial transformation (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in mouse models. |
| M10855 | Mephenytoin | Mephenytoin is an anticonvulsant that is a substrate for CYP2C19 and CYP2B6. |
| M10852 | M-4344 | VX-803 (M4344, ATR inhibitor 2) is a selective inhibitor of ATAxia telangiectasia and Rad3 related (ATR) kinase with a Ki value of less than 150 pM. VX-803 (M4344) effectively inhibits ATR-driven phosphorylated checkpoint kinase-1 (P-Chk1) phosphorylation with an IC50 value of 8 nM. VX-803 (M4344) has potential antitumor activity. |
| M10851 | LY2922470 | LY2922470 is an effective, selective, orally potent GPR40 agonist that acts on human GPR40, mouse GPR40, and rat GPR40 EC50 The values are 7 nM, 1 nM, and 3 nM, respectively. LY2922470 lowers blood glucose levels while significantly increasing insulin and GLP-1, potentially for use in the study of type 2 diabetes mellitus (T2DM). |
| M10848 | LP-922761 | LP-922761 is a potent, selective, orally active AAK1 inhibitor in enzymatic and cell analysis IC50 4.8 nM and 7.6 nM, respectively. LP-922761 also inhibits BMP-2-induced protein kinase (BIKE),IC50 24 nM. LP-922761 has no significant activity against cell GAK, opioids, epinephrine alpha2, or GABAa receptors. |
| M10836 | IPN60090 | IPN-60090 is an inhibitor of orally active and highly selective glutaminease 1 GLS1 (IC50=31 nM), inactive against GLS-2. IPN-60090 exhibits excellent physicochemical and pharmacokinetic properties in vivo. IPN-60090 can be used in the study of solid tumors such as lung and ovarian cancers. |
| M10834 | Indeglitazar | Indeglitazar (PPM 204) is an orally active PPAR pan-agonist that acts on PPARα, PPARδ and PPARγ. |
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