| Cat.No. | Name | Information |
|---|---|---|
| M9566 | Glycine | Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate. |
| M3003 | CB-839 | Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. |
| M2884 | NMDA | NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. |
| M2767 | Ifenprodil Tartrate | Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM. |
| M55428 | Glycine-d2 | Glycine-d2 |
| M53076 | CALP1 | CALP1 is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. |
| M39029 | Withanone | Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in Neuron-like cells. |
| M38963 | O-Phospho-L-serine | O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2. |
| M31353 | TAT-GluA2 3Y | TAT-GluA2 3Y is a GluA2-derived interfering peptide that blocks long-term depression (LTD) at glutamatergic synapses by preventing regulated endocytosis of AMPA receptors. |
| M30934 | FITM | FITM is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM. |
| M30528 | RO0711401 | RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM. |
| M30011 | Mibampator | Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors. |
| M29120 | JNJ-61432059 | JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models. |
| M29073 | Valiglurax | Valiglurax (VU0652957) is a potent, orally active and selective mGlu4 positive allosteric modulator with EC50 values of 64.6 nM and 197 nM for hmGlu4/Gqi5 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant. Valiglurax can be used in research of Parkinson's disease. |
| M28813 | Ro 25-6981 | Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD). |
| M27687 | Sepimostat | Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 µM. |
| M25474 | L-Glutamic acid monosodium salt | L-Glutamic acid monosodium salt is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). |
| M22410 | ADX88178 | ADX88178 |
| M21178 | TAK-653 | Osavampator (TAK-653) is a potential first-in-class alpha amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) enhancer. |
| M20645 | UPGL00004 | UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2. |
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