| Cat.No. | Name | Information |
|---|---|---|
| M3451 | Hydrocortisone | Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. |
| M29590 | AL-438 | AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity. |
| M29239 | OP-3633 | OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism. |
| M27922 | BI 653048 phosphate | BI 653048 phosphate is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. BI 653048 phosphate inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM). BI 653048 phosphate is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus. |
| M27921 | BI 653048 | BI 653048 is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM). BI 653048 is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus. |
| M27705 | Dagrocorat hydrochloride | Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis. |
| M27704 | Fosdagrocorat | Fosdagrocorat (PF-04171327) is a dissociated glucocorticoid receptor agonist. |
| M27703 | Dagrocorat | Dagrocorat (PF-00251802) is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat can be used for the research of rheumatoid arthritis. |
| M21281 | BAY 1003803 | BAY 1003803 is a glucocorticoid receptor agonist for the study of topical psoriasis or severe atopic dermatitis. |
| M13981 | Mapracorat | Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist. |
| M13980 | Glucocorticoid receptor agonist | Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist. IC50 value: Target: |
| M13979 | Fluorometholone | Fluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used for the research of dry eye. |
| M13975 | Desisobutyryl-ciclesonide | Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor. |
| M13974 | Clobetasone butyrate | Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis. |
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