| Cat.No. | Name | Information |
|---|---|---|
| M2167 | (+)-JQ1 | (+)-JQ1 is a BET bromodomain inhibitor that acts on BRD4(2) with an IC50 of 33 nM and binds to all bromodomain domains in the BET family, but not to bromodomain domains outside the BET family. JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway, and JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway. |
| M6118 | 666-15 | 666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM. |
| M2096 | I-BET151 | I-BET151 (GSK1210151A) is an inhibitor of the BET family with IC50 of 0.5 μM, 0.25 μM and 0.79 μM for BRD2, BRD3 and BRD4, respectively. |
| M2903 | OTX015 (Birabresib) | OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. |
| M2190 | I-BET-762 | I-BET-762 (GSK525762) is a selective small molecule BET inhibitor. |
| M7126 | PF CBP1 | PF CBP1 is a selective CBP/p300 bromodomain inhibitor. |
| M9218 | ABBV-744 | ABBV-744 is a first-in-class, orally active and selective inhibitor of the BDII domain of the BET family of proteins with IC50 values of 4-18 nM for BRD2, BRD3, BRD4, and BRDT for AML and metastatic desmoplasia-resistant prostate cancer. |
| M41660 | CBP-IN-1 | CBP-IN-1 is a potent CBP inhibitor, with an IC50 of 1.5 nM. |
| M41659 | PROTAC BRD4 Degrader-21 | PROTAC BRD4 Degrader-21 is a PROTAC degrader of BRD4. |
| M41658 | BET-IN-14 | BET-IN-14 is an orally active pan BET inhibitor (IC50: 5.35 nM). |
| M41657 | VinSpinIn | VinSpinIn is a Spindlin1 inhibitor (KD: 9.9 nM for SPIN149-262). |
| M41656 | IV-255 | IV-255 is a selective small molecule inhibitor of the BRG1 bromodomain. |
| M41655 | BET BD2-IN-1 | BET BD2-IN-1 is a potent and selective inhibitor of BET BD2 (IC50=1.6 nM). |
| M41653 | PROTAC BRD4 Degrader-20 | PROTAC BRD4 Degrader-20 is an bifunctional compound and an degrader of BRD4. |
| M41652 | GSK737 | GSK737 is a BRD4 BD1 and BD2 inhibitor, with pIC50 values of 5.3 and 7.3 respectively. |
| M41651 | GXF-111 | GXF-111, a PROTAC molecule, can promote selective degradation of cellular BRD3 and BRD4-L. |
| M41650 | BRD4 Inhibitor-27 | BRD4 Inhibitor-27 is a BRD4 inhibitor with IC50 of 9.6 and 11.3 μM for BRD4 BD1 and BRD4 BD2, respectively. |
| M41649 | TRIM24/BRPF1-IN-2 | TRIM24/BRPF1-IN-2 is a potent TRIM24/BRPF1 dual inhibitor, with IC50 values of 0.98 and 1.16 μM, respectively. |
| M41648 | BRD7-IN-2 | BRD7-IN-2 is a potent inhibitor of bromodomain-containing protein 7 (BRD7), targeting to prostate cancer cells. |
| M41647 | DC-BPi-11 hydrochloride | DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. |
| M41646 | BET-IN-15 | BET-IN-15 is a potent and orally active BET inhibitor with IC50 values of 0.64, 0.25 nM for BRD4-BD1, BRD4-BD2, respectively. |
| M41644 | Bromodomain inhibitor-12 | Bromodomain inhibitor-12 is a bromodomain inhibitor that can be used in the research of autoimmune and inflammatory diseases. |
| M41643 | PROTAC BRD3/BRD4-L degrader-2 | PROTAC BRD3/BRD4-L degrader-2 is a PROTAC molecule and can selectively degrade cellular BRD3 and BRD4-L with Ki values of 16.91 and 2.8 nM, respectively. |
| M41642 | Bromodomain IN-2 | BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. |
| M41641 | TCIP 1 | TCIP 1 is a transcriptional/epigenetic CIPs (TCIP) small molecule consisting of covalent links to small molecules capable of binding to BCL6 and capable of binding to BRD4, respectively. |
| M41640 | DDO-8926 | DDO-8926 is a potent and selective BET inhibitor that can significantly reduce mechanical hypersensitivity by inhibiting the expression of pro-inflammatory cytokines. |
| M41475 | SRX3177 | SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC50s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), 3.3 nM (CDK6), respectively. |
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