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PF CBP1

Cat. No. M7126

All AbMole products are for research use only, cannot be used for human consumption.

PF CBP1 Structure
Size Price Availability Quantity
10mg USD 115  USD115 In stock
25mg USD 220  USD220 In stock
50mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

PF CBP1 is a selective CBP/p300 bromodomain inhibitor (IC50 values are 0.13 and 18.1 μM, respectively). Exhibits >100-fold selectivity for CBP over BRD4. Also exhibits selectivity over a panel of other bromodomains. Reduces LPS-induced IL-1β, IL-6 and IFN-β expression in macrophages in vitro. Also downregulates RGS4 expression in primary cortical neurons in vitro.

Product Citations
Chemical Information
Molecular Weight 488.62
Formula C29H36N4O3
CAS Number 1962928-21-7
Solubility (25°C) DMSO 48.86 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Cho, et al. ACS Chem Biol. Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics.

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BBC0403 is a selective BRD2 inhibitor with Kds of 7.64 μM and 41.37 μM for BRD2 (BD2) and BRD2 (BD1), respectively.

BAY-155 

BAY-155 is a potent and selective menin-MLL tool inhibitor, with an IC50 of 8 nM.

FHT-1015 

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ISOX-DUAL 

ISOX-DUAL is a dual CBP/BRD4 inhibitor with IC50 values of 0.65 μM and 1.5 μM for CBP and BRD4, respectively.

  Catalog
Abmole Inhibitor Catalog




Keywords: PF CBP1 supplier, Epigenetic Reader Domain, inhibitors, activators

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