| Cat.No. | Name | Information |
|---|---|---|
| M2167 | (+)-JQ1 | (+)-JQ1 is a BET bromodomain inhibitor that acts on BRD4(2) with an IC50 of 33 nM and binds to all bromodomain domains in the BET family, but not to bromodomain domains outside the BET family. JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway, and JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway. |
| M6118 | 666-15 | 666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM. |
| M2096 | I-BET151 | I-BET151 (GSK1210151A) is an inhibitor of the BET family with IC50 of 0.5 μM, 0.25 μM and 0.79 μM for BRD2, BRD3 and BRD4, respectively. |
| M2903 | OTX015 (Birabresib) | OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. |
| M2190 | I-BET-762 | I-BET-762 (GSK525762) is a selective small molecule BET inhibitor. |
| M7126 | PF CBP1 | PF CBP1 is a selective CBP/p300 bromodomain inhibitor. |
| M9218 | ABBV-744 | ABBV-744 is a first-in-class, orally active and selective inhibitor of the BDII domain of the BET family of proteins with IC50 values of 4-18 nM for BRD2, BRD3, BRD4, and BRDT for AML and metastatic desmoplasia-resistant prostate cancer. |
| M3106 | UNC1215 | UNC1215 is a potent and selective MBT (malignant brain tumor) antagonist, which binds L3MBTL3 with IC50 of 40 nM and Kd of 120 nM, 50-fold selective versus other members of the human MBT family. |
| M3104 | UNC0638 | UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. |
| M2932 | PFI-1 | PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM. |
| M2219 | RVX-208 | Apabetalone (RVX-208) is a first-in-class, small molecule inhibitor of BET bromodomain with IC50 of 0.51 μM for BD2. |
| M2202 | CPI-0610 | CPI-0610 is a novel BET protein bromodomain inhibitor. |
| M57110 | dBRD9 dihydrochloride | dBRD9 dihydrochloride is a selective BRD9 PROTAC degrader. |
| M56049 | BBC0403 | BBC0403 is a selective BRD2 inhibitor with Kds of 7.64 μM and 41.37 μM for BRD2 (BD2) and BRD2 (BD1), respectively. |
| M56048 | BAY-155 | BAY-155 is a potent and selective menin-MLL tool inhibitor, with an IC50 of 8 nM. |
| M56047 | FHT-1015 | FHT-1015 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC50s of ≤10 nM. |
| M56046 | ISOX-DUAL | ISOX-DUAL is a dual CBP/BRD4 inhibitor with IC50 values of 0.65 μM and 1.5 μM for CBP and BRD4, respectively. |
| M56045 | BET-IN-19 | BET-IN-19 is a BET inhibitor. |
| M56044 | BAZ1A-IN-1 | BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). |
| M56043 | CBP/p300-IN-1 | CBP/p300-IN-1 is a CBP/EP300 bromodomain inhibitor. |
| M56042 | PROTAC BRD4 ligand-1 | PROTAC BRD4 ligand-1 is a potent BET inhibitor and a ligand for target BRD4 protein for PROTACT GNE-987. |
| M56041 | Bleximenib | Bleximenib (Menin-MLL inhibitor 24) is a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor. |
| M56040 | Emilumenib | Emilumenib (Menin-MLL inhibitor 26) is a Menin-MLL inhibitor. |
| M56039 | BET bromodomain inhibitor 1 | BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4. |
| M55624 | BN-104 | BN-104 (BNM-1192) is a novel, potent and highly selective, oral menin inhibitor. BN-104 (BNM-1192) can inhibit the Menin-MLL interaction. |
| M54048 | Phoenixin-20 | Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. |
| M53318 | Menin-MLL inhibitor 31 | Menin-MLL inhibitor 31 is a potent inhibitor of the menin MLL interaction with an IC50 value of 4.6 nM. |
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