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PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM.
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Source | Sci Rep (2017). Figure 1. PFI-1 |
| Method | flow cytometry | |
| Cell Lines | C11 cells or A10.6 cells | |
| Concentrations | 5 μM | |
| Incubation Time | 24 to 72 h | |
| Results | To determine the effect of RVX-208 and PFI-1 on latent HIV-1 reactivation, we used J-Lat C11 cell line in which transcriptional activation of the latent provirus can be detected in individual cells by flow cytometry, since these cells harbor full-length latent HIV-1 provirus containing GFP gene in place of nef |
| Molecular Weight | 347.39 |
| Formula | C16H17N3O4S |
| CAS Number | 1403764-72-6 |
| Solubility (25°C) | DMSO 18 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Panpan Lu, et al. BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency
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