Inhibitor/Agonist/Antagonist
| Cat.No. | Name | Information |
|---|---|---|
| M53258 | Apelin-13 | Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. |
| M14811 | Elabela(19-32) TFA | Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart. |
| M14810 | Elabela(19-32) | Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart. |
| M10208 | Apelin-36(rat, mouse) TFA | Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. |
| M10197 | (Glp1)-Apelin-13 human, bovine | (Glp1)-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist. |
| M10097 | Apelin-13 TFA | Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. |
| M6972 | ML221 | ML221 is an Apelin (APJ) antagonist and inhibits apelin-13-mediated activation of APJ. IC50 values of cAMP and β -Arrestin were 0.70 μM and 1.75 μM, respectively. EC80 values were all 10 nM. |
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