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Apelin-36(rat, mouse) TFA

Cat. No. M10208
Apelin-36(rat, mouse) TFA Structure
Size Price Availability
5mg USD 720  USD800 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) TFA blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ. Apelin-36(rat, mouse) TFA binds to APJ receptors with an IC50 of 5.4 nM, and potently inhibits cAMP production with an EC50 of 0.52 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 4314.91
Formula C187H305N68F3O45S
CAS Number 230299-95-3 (free base)
Purity >99%
Solubility Water
Storage -20°C, sealed
References

Molecular properties of apelin: tissue distribution and receptor binding
Y Kawamata, et al. Biochim Biophys Acta. 2001 Apr 23;1538(2-3):162-71. PMID: 11336787.

Apelin peptides block the entry of human immunodeficiency virus (HIV)
M X Zou, et al. FEBS Lett. 2000 May 4;473(1):15-8. PMID: 10802050.

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  Catalog
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