Free shipping on all orders over $ 500

Apelin-36(rat, mouse) TFA

Cat. No. M10208
Apelin-36(rat, mouse) TFA Structure
Size Price Availability
5mg USD 720  USD800 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) TFA blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ. Apelin-36(rat, mouse) TFA binds to APJ receptors with an IC50 of 5.4 nM, and potently inhibits cAMP production with an EC50 of 0.52 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 4314.91
Formula C187H305N68F3O45S
CAS Number 230299-95-3 (free base)
Purity >99%
Solubility Water
Storage -20°C, sealed

Molecular properties of apelin: tissue distribution and receptor binding
Y Kawamata, et al. Biochim Biophys Acta. 2001 Apr 23;1538(2-3):162-71. PMID: 11336787.

Apelin peptides block the entry of human immunodeficiency virus (HIV)
M X Zou, et al. FEBS Lett. 2000 May 4;473(1):15-8. PMID: 10802050.

Related HIV Protease Products

Cabotegravir, also known as S/GSK1265744 or GSK744, is potent HIV integrase inhibitor.

Tenofovir hydrate

Tenofovir hydrate is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.


Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM.

Diethyldithiocarbamate sodium

Sodium diethyldithiocarbamate is an accelerator of the rate of copper cementation. Sodium diethyldithiocarbamate reduces the incidence of HIV infection.

HIV-1 TAT Peptide TFA

TAT TFA is a cell-penetrating peptide which derived from the transactivator of transcription (TAT) of human immunodeficiency virus (HIV-1).

Abmole Inhibitor Catalog 2017

Keywords: Apelin-36(rat, mouse) TFA supplier, HIV Protease, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.