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(Glp1)-Apelin-13 human, bovine

Cat. No. M10197
(Glp1)-Apelin-13 human, bovine Structure
Synonym:

[Pyr1]-Apelin-13

Size Price Availability Quantity
5mg USD 345  USD345 In stock
10mg USD 540  USD540 In stock
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Quality Control & Documentation
Biological Activity

(Glp1)-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist. [Pyr1]-Apelin-13 improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats.

Chemical Information
Molecular Weight 1533.80
Formula C69H108N22O16S
CAS Number 217082-60-5
Solubility (25°C) Water
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zahra Hajimashhadi, et al. Neuropeptides. Chronic administration of [Pyr 1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats

[2] Vahid Serpooshan, et al. Biomaterials. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction

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