All AbMole products are for research use only, cannot be used for human consumption.
ML221 is an Apelin (APJ) antagonist and inhibits apelin-13-mediated activation of APJ. IC50 values of cAMP and β -Arrestin were 0.70 μM and 1.75 μM, respectively. EC80 values were all 10 nM.
| Molecular Weight | 385.35 |
| Formula | C17H11N3O6S |
| CAS Number | 877636-42-5 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Apelin Receptor Products |
|---|
| Apelin-13
Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. |
| Elabela(19-32) TFA
Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart. |
| Elabela(19-32)
Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart. |
| Apelin-36(rat, mouse) TFA
Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. |
| (Glp1)-Apelin-13 human, bovine
(Glp1)-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
