About 32 results found for searched term "i-Inositol" (0.101 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5704 | i-Inositol | Others |
| myo-inositol | ||
| i-Inositol, also known as myo-inositol, is a chemical compound which is sugar alcohol. i-Inositol is involved in a number of biological processes including insulin signal transduction, cytoskeleton transduction and so on. | ||
| M21007 | Phytic acid | Others |
| inositol polyphosphate, inositol hexakisphosphate | ||
| Phytic acid is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It can act as a cofactor in DNA repair by nonhomologous end-joining. | ||
| M30027 | Phosphatidylinositols, soya, sodium salts | Others |
| Phosphatidylinositols, soya, sodium salts is a mixture of phosphatidylinositols. Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They act by recruiting and/or activating effector proteins and thus are involved in regulating various cellular functions, such as vesicular budding, membrane fusion and cytoskeleton dynamics. | ||
| M52618 | Phosphatidylinositol phosphodiesterase | Metabolite/Endogenous Metabolite |
| Phosphatidylinositol phosphodiesterase hydrolyzes phosphatidylinositol to diacylglycerols and a mixture of myoinositol 1- and 1, 2-cyclic phosphates. | ||
| M1739 | PKI-179 | PI3K |
| PKI-179 is an orally dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor with potential antineoplastic activity. | ||
| M1795 | TGX-221 | PI3K |
| TGX-221 is a potent and specific cell permeable inhibitor of Phosphatidylinositol 3-kinase (PI3K) p110β(IC50 = 10nM). | ||
| M1878 | ZSTK474 | PI3K |
| ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3-kinase (PI3K), induces G1 arrest of the cell cycle in vivo. | ||
| M2053 | Wortmannin (KY 12420) | PI3K |
| SL-2052; KY-12420 | ||
| Wortmannin (KY 12420) is a specific, covalent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) with IC50 of 3 nM. | ||
| M2220 | GDC-0941 Bimesylate | PI3K |
| Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt); GDC-0941 | ||
| GDC-0941 Bimesylate is the orally bioavailable bismesylate salt of a potent inhibitor of the class I phosphatidylinositol 3 kinase (PI3K). | ||
| M2792 | Ki16198 | LPL Receptor |
| Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6. | ||
| M3186 | Isoprenaline hydrochloride | Animal Modeling |
| Isoproterenol hydrochloride | ||
| Isoproterenol hydrochloride is a non-selective β-adrenoceptor, inhibits the 3H-inositol phosphate accumulation with IC50 of 0.08 μM. | ||
| M4695 | D-Pinitol | Anti-infection |
| D-pinitol (3-O-methyl-D-Chiro-inositol) is a natural compound found in several plants, such as pinaceae and legumes. D-pinitol has hypoglycemic activity and cardiovascular system protection. D-pinitol has antiviral and larvicidal activities. | ||
| M5431 | Atosiban Acetate | Vasopressin Receptor |
| RW22164 acetate; RWJ22164 acetate | ||
| Atosiban (RW22164; Tractocile) Acetate is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra). Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. | ||
| M6881 | L-690,330 | Phosphatase |
| L-690,330 is a inositol monophosphatase inhibitor. | ||
| M8439 | SMI481 | Others |
| SMI481 is a selective small-molecule inhibitor (SMI) of the yeast phosphatidylinositol transfer protein (PITP) Sec14, a key regulator of phosphoinositide signaling, regulating membrane trafficking through the trans-Golgi network and endosomal systems. | ||
| M8904 | NIH-12848 | PI5P4K |
| NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor. | ||
| M9503 | E1210 | Anti-infection |
| APX001A; Manogepix | ||
| E1210 (APX001A) is the first-in-class inhibitor of the fungal protein Gwt1 (GPI-anchored wall transfer protein 1) in the glycosylphosphatidylinositol (GPI) biosynthesis pathway. | ||
| M10800 | Vanin-1-IN-1 | Others |
| Vanin-1-IN-1 is an inhibitor of the vanin-1 enzyme. Vanin-1 is a cell surface-associated inositol (GPi) anchored protein that plays an important role in metabolism and inflammation. | ||
| M13408 | SNAP 94847 hydrochloride | Others |
| SNAP 94847 Hydrochloride is a novel high affinity selective melanin concentration hormone receptor 1 (MCHR1) antagonist with antidepressant like activity. SNAP 94847 Hydrochloride is a high-affinity antagonist (pA2=7.81) of MYo-inositol phosphate formation induced by MCH. | ||
| M13685 | GSK2850163 | IRE1 |
| GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. | ||
| M14481 | 3α-Aminocholestane | Phosphatase |
| 3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM. | ||
| M20184 | WAY-601017 | PI3K |
| WAY-601017 is a phosphatidylinositol 3-kinase inhibitor | ||
| M20796 | ME-401 | PI3K |
| PWT-143, P110δ-IN-1 | ||
| ME-401 (PWT-143, P110δ-IN-1) is an oral, potent and selective inhibitor of Phosphatidylinositol 3-Kinase (PI3K) P110δ with IC50 of 0.6 nM in cellular assay. | ||
| M22485 | Recombinant Human CD14 (HEK293, C-6His) | Cytokines and Growth Factors |
| Monocyte Differentiation Antigen CD14 | ||
| Recombinant Human CD14 is produced by Mammalian expression system and the target gene encoding Thr20-Cys352 is expressed with a 6His tag at the C-terminus. CD14 is a cell surface glycoprotein that is preferentially expressed on monocytes/macrophages. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a pattern recognition receptor that binds lipopolysaccharides (LPS) and a variety of ligands derived from different microbial sources. | ||
| M24954 | Tamrintamab | Others |
| SC-003 mAb; SC-Mab003; SC34.28ss1 | ||
| Tamrintamab (SC-003 mAb, SC-Mab003, SC34.28ss1) is an ADC Antibody targeting to dipeptidase 3 (DPEP3 or MBD3). DPEP3 is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab can be used in ovarian cancer research. | ||
| M25293 | Amatuximab | Others |
| MORab-009 | ||
| Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium. | ||
| M27783 | I-OMe-Tyrphostin AG 538 | IGF-1R |
| I-OMe-AG 538 | ||
| I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM. | ||
| M28086 | Dezapelisib | PI3K |
| INCB040093 | ||
| Dezapelisib (NCB040093) is a potent inhibitor of phosphatidylinositol 3-kinase δ (PI3Kδ). Dezapelisib is a promising research strategy for select R/R B-cell lymphomas. | ||
| M28374 | GSK-A1 | PI3K |
| GSK-A1 is a selective type III phosphatidylinositol 4-kinase PI4KA (PI4KIIIα) inhibitor with a pIC50 of 8.5-9.8. GSK-A1 inhibits PtdIns(4,5)P2 resynthesis with an IC50 of about 3 nM. GSK-A1 potently decreases the levels of PtdIns(4)P with a negligible effect on PtdIns(4,5)P2. GSK-A1 has the potential for anti-hepatitis C virus (HCV) research. | ||
| M29839 | PIKfyve-IN-1 | PI3K |
| PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology. | ||
| M30424 | AL-3138 | Prostaglandin Receptor |
| 11-Deoxy-16-fluoro PGF2α | ||
| AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandin F2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production. | ||
| M30922 | PI-273 | PI3K |
| PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis. | ||
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