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Amatuximab

Cat. No. M25293

All AbMole products are for research use only, cannot be used for human consumption.

Amatuximab Structure
Synonym:

MORab-009

Price and Availability

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Quality Control & Documentation
Biological Activity

Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium.

Chemical Information
CAS Number 931402-35-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Yuki Fujii, et al. Invest New Drugs. Early administration of amatuximab, a chimeric high-affinity anti-mesothelin monoclonal antibody, suppresses liver metastasis of mesothelin-expressing pancreatic cancer cells and enhances gemcitabine sensitivity in a xenograft mouse model

[2] Fumihiko Matsuzawa, et al. BMC Cancer. Mesothelin blockage by Amatuximab suppresses cell invasiveness, enhances gemcitabine sensitivity and regulates cancer cell stemness in mesothelin-positive pancreatic cancer cells

[3] Nicholas C Nicolaides, et al. Cancer Biol Ther. CA125 suppresses amatuximab immune-effector function and elevated serum levels are associated with reduced clinical response in first line mesothelioma patients

[4] Paolo Baldo, et al. Onco Targets Ther. Amatuximab and novel agents targeting mesothelin for solid tumors

[5] Anubha Gupta, et al. Cancer Chemother Pharmacol. Population pharmacokinetics and exposure-response relationship of amatuximab, an anti-mesothelin monoclonal antibody, in patients with malignant pleural mesothelioma and its application in dose selection

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Keywords: Amatuximab, MORab-009 supplier, inhibitors, activators

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