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NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor. NIH-12848 inhibited PI5P4Kγ with an IC50 of approximately 1 μM but did not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. NIH-12848 is a potentially powerful tool for exploring the cell physiology of PI5P4Ks.
| Molecular Weight | 385.41 |
| Formula | C20H14F3N3S |
| CAS Number | 959551-10-1 |
| Solubility (25°C) | DMSO: ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PI5P4K Products |
|---|
| CC260
CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Ki values of 40 nM and 30 nM, respectively, and can be used in cellular energy metabolism, diabetes, and cancer research. |
| THZ-P1-2
THZ-P1-2 is a first-in-class, selective PI5P4K inhibitor with an IC50 of 190 nM for Pi5P4α. |
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