About 17 results found for searched term "X-34" (0.054 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2381 | AMD3465 hexahydrobromide (AMD3465 ) | CXCR |
| GENZ-644494 hexahydrobromide | ||
| AMD3465 hexahydrobromide（AMD3465 ) is an effective CXCR4 antagonist that inhibits 12G5 mAb in SupT1 cells. The IC50 values of CXCL12AF647 and CXCR4 were 0.75 nM and 18 nM, respectively. AMD 3465 also effectively inhibited X4 HIV replication (IC50, 1-10 nM), but not R5 HIV replication. | ||
| M4879 | Cycloheximide | DNA/RNA Synthesis |
| Naramycin A; Actidione; CHX; FT 3422-2; NM-MCD 80 | ||
| Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. | ||
| M6104 | Ipilimumab | Checkpoint |
| MDX-010, BMS-734016；Yervoy | ||
| Ipilimumab (MDX-010, BMS-734016) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD. | ||
| M8159 | STX64 | Others |
| STX64; BN83495; 667-Coumate | ||
| STX64 is a potent, irreversible inhibitor of steroid sulfatase. | ||
| M8711 | Delafloxacin | Others |
| Delafloxacinum; RX-3341; WQ-3034; ABT492; ABT 492; ABT-492 | ||
| Delafloxacin is a fluoroquinolone antibiotic active against both Gram-negative and Gram-positive bacteria such as MRSA. | ||
| M8750 | X-34 | Others |
| X-34 is a fluorescent, amyloid-specific dye. | ||
| M10070 | LX2343 | BACE |
| LX-2343 | ||
| LX2343 is a BACE1 enzyme inhibitor with IC50 value of 11.43±0.36 μM, and it is a neuroprotective agent. | ||
| M10905 | Pralnacasan | Caspase |
| VX-740; HMR 3480 | ||
| Pralnacasan (VX-740) is a potent, selective, non-peptide inhibitor with an oral active interleukin 1β-convertase (ICE, caspase 1) inhibitor,Ki 1.4 nM. Pralnacasan inhibits pro-inflammatory cytokines IL-18, IL-1β, and IFN-γ. Pralnacasan has the potential to be used in the study of osteoarthritis and rheumatoid arthritis. | ||
| M11251 | Gartisertib | ATM/ATR |
| VX-803; M4344; ATR inhibitor 2 | ||
| Gartisertib (VX-803) is an ATP-competitive, orally active, selective ATR inhibitor with Ki<150 pM. Gartisertib inhibits atR-driven phosphorylation of checkpoint kinase-1 (Chk1) with an IC50 value of 8 nM. It has antitumor activity. | ||
| M19870 | Delafloxacin Meglumine | Antibiotic |
| ABT-492; RX-3341; WQ-3034; Baxdela | ||
| Delafloxacin (ABT-492, RX-3341, WQ-3034, Baxdela) meglumine is a broad-spectrum fluoroquinolone antibiotic against multiple pathogens. | ||
| M21947 | Bifluranol | Others |
| BX341 | ||
| Bifluranol | ||
| M24600 | Lampalizumab | Complement System |
| RG 7417; TNX 234; Anti-CFD Recombinant Antibody | ||
| Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research. | ||
| M24774 | MDX-1342 | Others |
| MDX-1342 is a fully human monoclonal antibody (HuMAb) of targeting CD19-membrane receptor. MDX-1342 can specifically bind to human CD19 antigen with high affinity and has antibody-dependent cellular cytotoxicity (ADCC) effect. MDX-1342 can be used for the research of B-lymphocyte malignancies and autoimmune. | ||
| M29626 | P2X3 antagonist 34 | P2 Receptor |
| P2X3 antagonist 34 is a potent, selective and orally active P2X3 homotrimeric receptor antagonist with IC50s of 25 nM, 92 nM and 126 nM for human P2X3, rat P2X3 and guinea pig P2X3 receptors, respectively. P2X3 antagonist 34 is less active against human, rat and guinea pig P2X2/3 heterotrimeric receptors. P2X3 antagonist 34 has strong anti-tussive effect. | ||
| M30848 | PRX-07034 hydrochloride | 5-HT Receptor |
| PRX-07034 hydrochloride is a highly selective and potent 5-HT6 receptor antagonist with a Ki= 4-8 nM and an IC50 of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility. | ||
| M41972 | COX-2-IN-34 | COX |
| COX-2-IN-34 is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. | ||
| M49913 | Clazosentan | Endothelin Receptor |
| Ro 61-1790; VML 588; AXV-034343 | ||
| Clazosentan is a potent, selective endothelin A receptor (ETA receptor) antagonist and inhibits ET-1-mediated vasoconstriction. It can be used in studies related to cerebral vasospasm, vasospasm-associated cerebral infarction and cerebral ischemia. | ||
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