About 31 results found for searched term "Thyroid Hormone Receptor" (0.205 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M40874 | Recombinant Human PTH1R (HEK293, C-6His) | Cytokines and Growth Factors |
| Parathyroid Hormone 1 Receptor | ||
| Parathyroid hormone 1 receptor (PTH1R) is a protein that in humans is encoded by the PTH1R gene, it belongs to the G-protein coupled receptor 2 family. PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP). | ||
| M43608 | Thyroid hormone receptor beta agonist-1 | Thyroid Hormone Receptor |
| Thyroid hormone receptor beta agonist-1 is a thyroid beta-agonist. | ||
| M58468 | Thyroid hormone receptor antagonist (1-850) | Thyroid Hormone Receptor |
| THR antagonist 1-850 | ||
| Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC50 of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. | ||
| M2815 | Liothyronine Sodium | Thyroid Hormone Receptor |
| T3 Sodium salt; Sodium L-3,3',5-triiodothyronine; Liothyronine sodium | ||
| Liothyronine Sodium is the most potent form of thyroid hormone acting on the body to increase the basal metabolic rate, affect protein synthesis. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively. | ||
| M3184 | Resmetirom (MGL-3196) | Thyroid Hormone Receptor |
| VIA-3196; MGL-3196 | ||
| Resmetirom (MGL-3196, VIA-3196, resmetirom) is a potentially first-in-class, liver-targeted, orally active, selective thyroid hormone receptor (THR)-β agonist with an EC50 value of 0.21 μM. Resmetirom avoids the activation of THR-α receptors that mediate thyroid hormone activity outside of the liver, including the heart and bone. Resmetirom avoids the activation of THR-α receptors that mediate extrahepatic (including cardiac and skeletal) thyroid hormone activity and can be used in studies of non-alcoholic steatohepatitis (NASH). | ||
| M4512 | Tectoridin | Estrogen Receptor |
| Tectoridin is an isoflavone isolated from Maackia Amurensis. Tectoridin is a phytoestrogen that activates estrogen and thyroid hormone receptors. Tectoridin exerts estrogenic effects through the ER dependent genomic pathway and the GPR30 dependent non-genomic pathway. | ||
| M6079 | Liothyronine | Thyroid Hormone Receptor |
| T3; 3,3',5-Triiodo-L-thyronine; L-3,3',5-Triiodothyronine; Tresitope | ||
| Liothyronine (3,3',5-Triiodo-L-thyronine; T3) is a potent agonist of both thyroid hormone receptors TRα and Trβ with Kis of 2.3 nM for both. This product is soluble but easy to precipitate after freezing in DMSO. NaOH is recommended as a stock solution. | ||
| M6190 | Calcium-Sensing Receptor Antagonists I | Calcium-sensing Receptor |
| Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. | ||
| M6746 | Sobetirome | Thyroid Hormone Receptor |
| GC-1; QRX-431 | ||
| Sobetirome is a thyroxine mimetic and a high affinity agonist for the thyroid hormone receptors THR-β and THR-α (KD values 67 and 440 pM, respectively). The in vitro effects on TRα1 and TRβ1 receptors are 5 and 100 times stronger than those of the endogenous agonist T3, respectively. | ||
| M25600 | MB-07811 | Thyroid Hormone Receptor |
| VK2809 | ||
| MB-07811 (VK2809) is an orally active, thyroid hormone receptor (THR)-beta agonist that can be used in studies related to hyperlipidemia and nonalcoholic steatohepatitis (NASH). | ||
| M8278 | MLS000389544 | Others |
| MLS000389544 is a selective and potent methylsulfonylnitrobenzoa |
||
| M9507 | ML-109 | TSH Receptor |
| ML-109 is a full agonist of TSHR (thyroid stimulating hormone receptor) with an EC50 of 40 nM. | ||
| M10319 | Parathyroid Hormone (1-34), bovine Acetate | Others |
| Parathyroid Hormone (1-34), bovine Acetate is a potent parathyroid hormone (PTH) receptor agonist. | ||
| M10689 | ML224 | TSH Receptor |
| NCGC00242364; ANTAG3 | ||
| ML224 (NCGC00242364; ANTAG3) is a thyroid-stimulating hormone receptor TSHR counter-agonist with an IC50 of 2.1uM. | ||
| M14798 | TR antagonist 1 | Others |
| TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively. | ||
| M14799 | Abaloparatide TFA | Others |
| BA 058 TFA; BIM 44058 TFA | ||
| Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue selected to be a potent and selective activator of the PTHR1 signaling pathway. | ||
| M20996 | Eprotirome (KB2115) | Thrombopoietin/Thrombin |
| Eprotirome (KB2115) is a liver-selective agonist of thyroid hormone receptor (TR). Eprotirome is investigated for the potential treatment of dyslipidemias and obesity. | ||
| M21091 | DS69910557 | Others |
| DS69910557 is an oral parathyroid hormone (PTH) type 1 receptor (PTHR1) inhibitor that is being developed as a hypercalcemic compound. | ||
| M27877 | VA-K-14 hydrochloride | TSH Receptor |
| VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM). | ||
| M28509 | KB130015 | Thyroid Hormone Receptor |
| KB015 | ||
| KB130015 (KB015) is an orally active and potent ThRα and ThRβ (Thyroid Hormone Receptor) inhibitor, with IC50 values of 4.5 and 5.1 μM, respectively. KB130015 has antiarrhythmic properties. KB130015 markedly slows the kinetics of inactivation of Na+ channels. KB130015 opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle. | ||
| M29864 | Org41841 | TSH Receptor |
| Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. | ||
| M30110 | NH-3 | Thyroid Hormone Receptor |
| NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment. | ||
| M30724 | AH3960 | Androgen Receptor |
| AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC50 value of 0.82 μM. AH3960 also serves as an agonist of parathyroid hormone receptor-1 (PTHR1). | ||
| M40538 | MBX-2109 | Thyroid Hormone Receptor |
| MBX-2109 is a long-acting parathyroid hormone receptor (PTH1R) agonist for studies related to hypoparathyroidism. | ||
| M40979 | TERN-501 | Thyroid Hormone Receptor |
| TERN-501 is a thyroid hormone receptor beta (THR-β) agonist that may be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M43606 | THR-β agonist 6 | Thyroid Hormone Receptor |
| THR-β agonist 6 is an orally active, selective thyroid hormone receptor β (THR-β) agonist with EC50s of 0.03 μM and 0.22 μM for THR-β and THR-α, respectively. | ||
| M43607 | THR-β modulator-1 | Thyroid Hormone Receptor |
| THR-β modulator-1 is a potent thyroid hormone receptor β modulator. | ||
| M43807 | ABX-002 | Thyroid Hormone Receptor |
| ABX-002 is a selective, CNS-permeable thyroid hormone receptor beta (THR-β) agonist for use in studies related to major depressive disorder (MDD). | ||
| M45132 | Palopegteriparatide | Others |
| TransCon PTH | ||
| Palopegteriparatide is a long-acting precursor compound of parathyroid hormone (PTH), as well as a calcium-sensitive receptor (CaSR) antagonist, and a parathyroid hormone receptor (PTH1R) modulator, and may be used in studies related to hypoparathyroidism (HP). | ||
| M50375 | DPC-AJ1951 | Thyroid Hormone Receptor |
| DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). | ||
| M53956 | TIP 39, Tuberoinfundibular Neuropeptide | Adenylate Cyclase |
| TIP 39, Tuberoinfundibular Neuropeptide is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. | ||
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